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Meningococcal meningitis factsheet. Global epidemiology of meningococcal disease. Meningococcal disease. N Engl J Med. The changing and dynamic epidemiology of meningococcal disease. Clin Microbiol Rev. Meningococcal disease: The organism, clinical presentation, and worldwide epidemiology. J Travel Med. Advances in the development of vaccines against Neisseria meningitidis. Meningococcal vaccines: WHO position paper, November Weekly epidemiological record.
European Centre for Disease Prevention and Control. Meningococcal vaccines: WHO position paper. November Instituto Carlos III. Bol Epidemiol Sem. Cano R, Garrido M. The burden of hospitalizations for meningococcal infection in Spain Neisseria meningitidis : Epidemiology, treatment and prevention in adolescents. Curr Opin Pediatr. Management of bacterial meningitis and meningococcal septicaemia in children and young people: Summary of NICE guidance. Global and regional risk of disabling sequelae from bacterial meningitis: A systematic review and meta-analysis.
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Lancet Infect Dis. Lancet Neurol. Saliva and meningococcal transmission. Emerg Infect Dis. Department of Health, Victoria, Australia. Infectious diseases. Disponible en: ideas. Meningococcal carriage and disease-population biology and evolution. Impact of meningococcal vaccination with combined serogroups A and C polysaccharide vaccine on carriage of Neisseria meningitidis C.
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J Med Microbiol. Genetic analysis of meningococci carried by children and young adults. J Infect Dis. The Stonehouse survey: Nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol Infect. Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population. J Clin Microbiol. Social behavior and meningococcal carriage in British teenagers. The systemic inflammatory response syndrome SIRS , sepsis, and septic shock. Principles and practice of pediatric infectious diseases. Philadelphia: Churchill Livingstone; Pollard A, Finn A.
Neisseria meningitidis. Philadelphia: Churchill Livingstone Elsevier; Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review. Update on meningococcal disease with emphasis on pathogenesis and clinical management. American Academy of Paediatrics. Meningococo, infecciones.
Red Book: Enfermedades Infecciosas en Pediatria. Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles. Expert Opin Biol Ther. The Global Meningococcal Initiative: Recommendations for reducing the global burden of meningococcal disease. Epidemiology and prevention of meningococcal disease: A critical appraisal of vaccine policies.
Expert Rev Vaccines. Yogev R, Tan T. Meningococcal disease: The advances and challenges of meningococcal disease prevention. Hum Vaccin. Changing epidemiology of meningococcal disease in Europe from the midth to the early 21st Century. Protection from routine vaccination at the age of 14 months with meningococcal serogroup C conjugate vaccine in the Netherlands.
Pediatr Infect Dis J. Impact and effectiveness of meningococcal C conjugate vaccine following its introduction in Spain. Ministerio de Sanidad y Consumo, Microbiology and public health: new challenges in surveillance and control of meningococcal disease.
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Enferm Infecc Microbiol Clin. Principi N, Esposito S. Universal protein vaccines against Neisseria meningitidis serogroup B, Streptococcus pneumoniae and influenza. A combination recombinant protein and outermembrane vesicle vaccine against serogroup B meningococcal disease. Delivering a safe and effective strain-specific vaccine to control an epidemic of group B meningococcal disease. Euro Surveill. Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil.
Immunogenicity of two investigational serogroup B meningococcal vaccines in the first year of life: A randomized comparative trial. Neisseria meningitidis B vaccines.
Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial. Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease.
Biotechnology and vaccines: Application of functional genomics to Neisseria meningitidis and other bacterial pathogens.
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J Biotechnol. Rappuoli R. Reverse vaccinology, a genome-based approach to vaccine development. Genome-based vaccine development: A short cut for the future. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Developing vaccines in the era of genomics: A decade of reverse vaccinology.
Clin Microbiol Infect. A universal vaccine for serogroup B meningococcus. Early clinical experience with a candidate meningococcal B recombinant vaccine rMenB in healthy adults. Multicenter, open-label, randomized phase II controlled trial of an investigational recombinant Meningococcal serogroup B vaccine with and without outer membrane vesicles, administered in infancy. Clin Infect Dis.
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Bactericidal antibody persistence two years following meningococcal B vaccination at 6, 8, and 12 months in month old children. Disponible en: www. Persistence of bactericidal antibodies following early infant immunisation with serogroup B meningococcal vaccines and immunogenicity of pre-school booster doses-a follow-on study. Poster No Immunogenicity and tolerability of recombinant serogroup B meningococcal vaccine administered with or without routine infant vaccinations according to different immunization schedules: A randomized controlled trial.
Immunogenicity of an investigational, multicomponent, meningococcall serogroup B vaccine in healthy infants at 2, 4, and 6 months of age. Tolerability of a three-dose schedule of an investigational, multicomponent, meningococcal serogroup B vaccine and routine infant vaccines in a lot consistency trial. Catch-up vaccination of healthy toddlers with an investigational multicomponent meningococcal serogroup b vaccine 4 cmenb -exploration of a two-dose schedule. Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.
Interlaboratory standardization of the sandwich enzyme-linked immunosorbent assay designed for MATS, a rapid, reproducible method for estimating the strain coverage of investigational vaccines. Clin Vaccine Immunol. Estimating the potential strain coverage in Europe of a multicomponent vaccine targeting serogroup b meningococci. Strain coverage of a meningococcal multicomponent 4 CMenB vaccine in Spain. Servicios Personalizados Revista.
Mode of transmission and clinical manifestations Carriage and transmission of meningococcal disease Humans are the only known reservoir of N. Prevention Chemoprophylaxis There are two types of transmission sources: the asymptomatic carrier and the symptomatic patient. The four-component vaccine against Meningococcus B: a new vaccine approach against serogroup B Meningococcus Reverse vaccinology Traditionally, vaccine development has been based on laboratory culture of organisms for the isolation and potential manipulation of their components.
Design of the four-component vaccine against meningococcus B by reverse vaccinology The development of a serogroup B meningococcal vaccine constitutes the first example of the successful application reverse vaccinology. Recommended vaccination strategy: posology proposed to the European Medicines Agency Table 5 presents the posology proposed to the European Medicines Agency.
Conflicts of interest D. Uriel has provided consultation for Novartis.
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