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Filter specialty. Submit To The Journals. In Partnership. Submit to the Journals. The following is noteworthy research into treatment for lung cancer. Researchers are looking for ways to improve surgical techniques and reduce side effects. Robot-assisted thoracoscopic surgery uses robotic arms to do surgery inside the chest. Researchers compared robot-assisted thoracoscopic surgery to standard surgical methods, including video-assisted thoracoscopic surgery VATS and removing part of the lung through a larger cut incision in the chest open lobectomy.
They found that there was little difference between the 3 techniques and overall survival was the same.
Peptide Hormone Production Associated with Small Cell Lung Cancer
Microcoils are very thin, twisted loops of metal usually platinum. Canadian researchers have developed a new method that uses microcoils to help surgeons find pulmonary nodules very small lung cancer tumours during VATS. Before surgery, the surgeon uses a CT scan to locate the nodule and place a microcoil into it. The surgeon then uses the image of the microcoil during surgery to find and remove the nodule. Radiofrequency ablation RFA uses heat from an electric current to destroy tissue.
The study showed that RFA did not affect lung function and that it worked better in healthier people who had tumours that were smaller than 2 cm. It also found that people who were treated with RFA survived for 2 years, which is similar to the survival rate for people who were treated with radiation therapy Cancer, PMID Another study looked at using RFA in people who had lung cancer that had spread outside the lung.
Find out more about research in cancer surgery. Researchers are looking for new chemotherapy drugs and new ways to combine current chemotherapy drugs to improve treatment for lung cancer. Improving scheduling and doses of chemotherapy may help make chemotherapy work better and with fewer side effects. Some research is looking at metronomic chemotherapy to treat lung cancer. Improving time and order sequence of chemotherapy is another area of lung cancer research. Chemotherapy is often used along with other treatments for lung cancer. Alternating chemotherapy with targeted therapy seems to be effective for treating certain lung cancers Anticancer Research, PMID Find out more about research in chemotherapy.
Targeted therapy is an important part of treatment for lung cancer. Researchers are looking for new drugs that can be used when cancer becomes resistant to current targeted therapies. They are also looking for more effective ways to combine targeted therapy with other treatments. Epidermal growth factor receptor EGFR targeted therapy can be used to treat lung cancer. EGFR is a receptor on the surface of cells that sends signals to cells that allow them to grow and divide. A mutation in the EGFR gene can cause cancer cells to grow and divide more than normal. Anaplastic lymphoma kinase ALK targeted therapy may be used to treat lung cancer.
ALK is a protein that helps with cell growth and division.
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It is controlled by the ALK gene. Some non—small cell lung cancers have an ALK gene mutation that causes the cancer cells to grow and spread. It is being used to treat lung cancers with the ALK gene mutation. Researchers are studying other ALK targeted drugs in clinical trials. Vascular endothelial growth factor VEGF targeted therapy may be used to treat advanced non—small cell lung cancer.
VEGF is one of the main proteins that help build a blood supply, which a small tumour needs to grow. Anti-angiogenesis drugs slow or stop the growth of new blood vessels. Cutting off the blood supply will starve a tumour of oxygen and nutrients, which it needs to grow. Bevacizumab Avastin is an anti-angiogenesis drug used to treat lung cancer. They are also looking at combining anti-angiogenesis drugs with neoadjuvant chemotherapy Oncotarget, PMID Combination targeted therapy uses drugs that work in different ways to target different mutated proteins or genes in cancer cells.
Monoclonal antibodies are a type of targeted immunotherapy that binds to specific antigens on cancer cells to help destroy them. They are a promising area of research for lung cancer because they use different targets than the drugs that are currently being used to treat the disease. Antibody drug conjugates are a type of targeted therapy that uses monoclonal antibodies to deliver chemotherapy.
They target proteins on the surface of some cancer cells.
Treatment of Small Cell Lung Cancer in the Elderly
Natural killer NK cell immunotherapy is being studied in clinical trials to treat lung cancer. Natural killer NK cells are often the first line of defence of the immune system against cancer cells. Allogenic NK cell immunotherapy involves transplanting NK cells from a donor to the person with cancer. Researchers are studying NK cell immunotherapy with cryotherapy to treat non—small cell lung cancer in clinical trials Immunologic Research, PMID Find out more about research in targeted therapy. Proton beam radiation therapy is a form of external beam radiation therapy that uses high-energy, or charged, proton particles instead of x-ray beams.
Protons can be aimed more precisely at the tumour so they deliver a higher dose of radiation but cause less damage to nearby tissues than conventional external beam radiation therapy. Researchers are studying techniques such as pencil beam scanned intensity-modulated proton therapy IMPT to further improve proton beam radiation therapy. Image-guided radiation therapy IGRT uses imaging to make radiation therapy more accurate.
Dose-escalation radiation therapy gradually increases the radiation dose to both improve its tolerability and maximize its effect. Post-operative radiation therapy is radiation therapy given after surgery. A recent meta-analysis looked at clinical trials using post-operative radiation therapy for people whose cancer was completely removed with surgery. Researchers concluded that radiation therapy should not be offered after surgery to people who have non—small cell lung cancer that was completely removed with surgery Cochrane Database of Systematic Reviews, PMID Another meta-analysis looked at using post-operative radiation, with or without chemotherapy, in people with stage IIIA non—small cell lung cancer that had spread to the lymph nodes on the same side of the body as the tumour N2.
The analysis found that giving post-operative radiation therapy to these people lowered the risk that the cancer would come back in the same area and improved overall survival. This improvement was found whether or not a person was given chemotherapy as well ASCO, Abstract Find out more about research in radiation therapy. Living with cancer can be challenging in many different ways. Supportive care can help people cope with cancer, its treatment and possible side effects.
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The following is noteworthy research into supportive care for lung cancer. Web-mediated follow-up allows doctors to use the Internet to monitor and follow up with people with lung cancer, who use a web browser to view and respond to questions and report any symptoms.
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Studies show that web-mediated follow-up along with routine imaging tests can find lung cancer relapse early and improves performance status at relapse. As a result, web-mediated follow-up can improve overall survival for people with lung cancer. Anamorelin is a drug that increases appetite and changes the way the body uses the energy it gets from food.
People with lung cancer often have severe loss of body weight and muscle mass called cachexia , which lowers their quality of life and shortens survival. In 2 recent clinical trials, people with advanced lung cancer were given anamorelin or a placebo. The studies showed that people who received anamorelin kept or gained lean muscle in their bodies and gained significantly more body weight than people who received the placebo.
Sodium alginate is a substance found in brown seaweed. Physical activity may help improve quality of life for people with lung cancer. One study found that survivors who followed a walking program had lower anxiety and depression than survivors who did not do any physical activity British Journal of Cancer, PMID , PMID
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